TX 8 - RD12/0021/0021 - Grupo de Carlos López Larrea

Investigador Principal	Dr. Carlos López Larrea
Segundo contacto	Dra. Aurora Menéndez González
Área temática y líneas de trabajo	1. Implicación del receptor NKG2D en el trasplante renal. Mecanismos de regulación epigenética e implicaciones funcionales. 2. Estudio de la contribución de los ligandos de NKG2D (MICA, MICB y ULBPs) al daño renal crónico y complicaciones post-trasplante. 3. Identificación de biomarcadores (epigenéticos) predictores del estatus inmunológico en pacientes trasplantados renales. 4. Estudio de la regulación epigenética implicada en los procesos de diferenciación del sistema inmune, y su contribución al desarrollo de patologías. 5. Importancia del desarrollo de anticuerpos no-HLA (MICA) y HLA de clase II en el periodo post-trasplante.
Investigadores Asociados al Dr. López Larrea
Publicaciones RedinRen Publicaciones del redinren por grupo Secretory pathways generating immunosuppressive NKG2D ligands: New targets for therapeutic intervention. Baragaño Raneros A, Suarez-Álvarez B, López-Larrea C.. Oncoimmunology. 2014;Apr 25;3:e28497. . . ;. Relationship between functional ability in older people, immune system status, and intensity of response to CMV. Moro-García MA, Alonso-Arias R, López-Vázquez A, Suárez-García FM, Solano-Jaurrieta JJ, Baltar J. Age (Dordr). 2012 Apr;34(2):479-95. A promoter DNA demethylation landscape of human hematopoietic differentiation. Calvanese V, Fernández AF, Urdinguio RG, Suárez-Alvarez B, Mangas C, Pérez-García V. Nucleic Acids Res. 2012 Jan;40(1):116-31. Expression of ERp5 and GRP78 on the membrane of chronic lymphocytic leukemia cells: association with soluble MICA shedding. Huergo-Zapico L, Gonzalez-Rodriguez AP, Contesti J, Gonzalez E, López-Soto A, Fernandez-Guizan A. Cancer Immunol Immunother. 2012 Aug;61(8):1201-10. A high density SNP genotyping approach within the 19q13 chromosome region identifies an association of a CNOT3 polymorphism with ankylosing spondylitis. Díaz-Peña R, Aransay AM, Suárez-Álvarez B, Bruges-Armas J, Rodríguez-Ezpeleta N, Regueiro M. Ann Rheum Dis. 2012 May;71(5):714-7. A predictive model of treatment outcome in patients with chronic HCV infection using IL28B and PD-1 genotyping. Vidal-Castiñeira JR, López-Vázquez A, Alonso-Arias R, Moro-García MA, Martinez-Camblor P, Melón S. J Hepatol. 2012 Jun;56(6):1230-8. The origin of the bacterial immune response. Martínez-Borra J, González S, López-Larrea C. Adv Exp Med Biol. 2012;738:1-13. Autophagy and self-defense. Martínez-Borra J, López-Larrea C. Adv Exp Med Biol. 2012;738:169-84. The emergence of the major histocompatilibility complex. Martínez-Borra J, López-Larrea C. Adv Exp Med Biol. 2012;738:277-89. Sensing in nature. Preface. López-Larrea C. Adv Exp Med Biol. 2012;739:v-vii. Immunology and the challenge of transplantation. Alonso Arias R, López-Vázquez A, López-Larrea C. Adv Exp Med Biol. 2012;741:27-43. Mobilization and homing of hematopoietic stem cells. Suárez-Álvarez B, López-Vázquez A, López-Larrea C. Adv Exp Med Biol. 2012;741:152-70. Ankylosing spondylitis in three Sub-Saharan populations: HLA-B27 and HLA-B14 contribution. Díaz-Peña R, Ouédraogo DD, López-Vázquez A, Sawadogo SA, López-Larrea C. Tissue Antigens. 2012 Jul;80(1):14-5. Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation. Serrano-Pertierra E, Cernuda-Morollón E, López-Larrea C. Eur J Immunol. 2012 Aug;42(8):2142-51. Oral supplementation with Lactobacillus delbrueckii subsp. bulgaricus 8481 enhances systemic immunity in elderly subjects. Moro-García MA, Alonso-Arias R, Baltadjieva M, Fernández Benítez C, Fernández Barrial MA, Díaz Ruisánchez E. Age (Dordr). 2013 Aug;35(4):1311-26. DNA methylation: a promising landscape for immune system-related diseases. Suarez-Alvarez B, Rodriguez RM, Fraga MF, López-Larrea C. Trends Genet. 2012 Oct;28(10):506-14. Old and new HLA associations with ankylosing spondylitis. Díaz-Peña R, López-Vázquez A, López-Larrea C. Tissue Antigens. 2012 Sep;80(3):205-13. Intensity of the humoral response to cytomegalovirus is associated with the phenotypic and functional status of the immune system. Alonso Arias R, Moro-García MA, Echeverría A, Solano-Jaurrieta JJ, Suárez-García FM, López-Larrea C. J Virol. 2013 Apr;87(8):4486-95. Genetic study confirms association of HLA-DPA1(∗)01:03 subtype with ankylosing spondylitis in HLA-B27-positive populations. Díaz-Peña R, Castro-Santos P, Aransay AM, Brüges-Armas J, Pimentel-Santos FM, López-Larrea C. Hum Immunol. 2013 Jun;74(6):764-7. When Aging Reaches CD4+ T-Cells: Phenotypic and Functional Changes. Moro-García MA, Alonso-Arias R, López-Larrea C. Front Immunol. 2013;4:107. Molecular mechanisms involved in the aging of the T-cell immune response. Moro-García MA, Alonso-Arias R, López-Larrea C. Curr Genomics. 2012 Dec;13(8):589-602. Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. International Genetics of Ankylosing Spondylitis Consortium (IGAS), Cortes A, Hadler J, Pointon JP, Robinson PC, Karaderi T. Nat Genet. 2013 Jul;45(7):730-8. Epigenetic modulation of the immune function: a potential target for tolerance. Suárez-Álvarez B, Baragaño Raneros A, Ortega F, López-Larrea C. Epigenetics. 2013 Jul;8(7):694-702. The arthritis-associated HLA-B27:05 allele forms more cell surface B27 dimer and free heavy chain ligands for KIR3DL2 than HLA-B27:09. Cauli A, Shaw J, Giles J, Hatano H, Rysnik O, Payeli S. Rheumatology (Oxford). 2013 Nov;52(11):1952-62. Correction: DNA Methylation Dynamics in Blood after Hematopoietic Cell Transplant. Rodriguez RM, Suarez-Alvarez B, Salvanés R, Muro M, Martínez-Camblor P, Colado E. PLoS One. 2013;8(9):e56931. NKG2D- and CD28-mediated costimulation regulate CD8+ T cell chemotaxis through different mechanisms: the role of Cdc42/N-WASp. Serrano-Pertierra E, Cernuda-Morollón E, López-Larrea C. J Leukoc Biol. 2014 Mar;95(3):487-95. Frequent participation in high volume exercise throughout life is associated with a more differentiated adaptive immune response. Moro-García MA, Fernández-García B, Echeverría A, Rodríguez-Alonso M, Suárez-García FM, Solano-Jaurrieta JJ. Brain Behav Immun. 2014;39:61-74. Role of BRD4 in hematopoietic differentiation of embryonic stem cells. Rodriguez RM, Suarez-Alvarez B, Salvanés R, Huidobro C, Toraño EG, Garcia-Perez JL. Epigenetics. 2014 Apr 1;9(4):566-78. Autoantibodies against MHC class I polypeptide-related sequence A are associated with increased risk of concomitant autoimmune diseases in celiac patients. López-Vázquez A, Mozo L, Alonso-Arias R, Suárez-Álvarez B, Vidal-Castiñeira JR, Arranz E. BMC Med. 2014 Feb 25;12:34. Immunosenescence and inflammation characterize chronic heart failure patients with more advanced disease. Moro-García MA, Echeverría A, Galán-Artímez MC, Suárez-García FM, Solano-Jaurrieta JJ, Avanzas-Fernández P. Int J Cardiol. 2014 ;174:590-9. L-plastin is involved in NKG2D recruitment into lipid rafts and NKG2D-mediated NK cell migration. Serrano-Pertierra E, Cernuda-Morollón E, Brdička T, Hooejši V, López-Larrea C. J Leukoc Biol. 2014 May 6;. DNA demethylation and histone H3K9 acetylation determine the active transcription of the NKG2D gene in human CD8+ T and NK cells. Fernández-Sánchez A, Baragaño Raneros A, Carvajal Palao R, Sanz AB, Ortiz A, Ortega F. Epigenetics. 2013 Jan;8(1):66-78.

Red financiada con fondos del Instituto de Salud Carlos III (ISCIII) y del Fondo Europeo de Desarrollo Regional (FEDER)

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